European Joint Program on Rare Diseases EJP RD Call 2022 is Open for Applications!

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The European Joint Program on Rare Diseases (EJP RD) (http://www.ejprarediseases.org/ ) is an international platform composed of 130 institutions and organizations from 35 countries supported by the European Commission within the framework of the Horizon 2020 Programme. Its aim is to create urgent, rational strategies needed in the European rare diseases research field, to discover fast and low-cost drugs through innovative clinical studies and to develop special care methods that will improve the quality of life of patients.

The EJP RD 2022 call for international joint research projects will support research projects on “Development of new analytical tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”.

Deadline for Application: 16 February 2022 (14:00, CET)

The research project proposals of the project consortia that will apply to the call should include at least one of the following sub-areas:

  1. Phenotype-driven diagnosis: integration across different ontologies, integration of shared pathways, digital phenotyping, development of artificial intelligence approaches/applications to extract health related data in aid of diagnosis;
  2. Prognostic markers/biomarkers investigations for early diagnosis and monitoring;
  3. Methodologies for solving cases that are currently difficult to analyse due to different underlying mechanisms (e.g. mosaicism, genomic (non-coding) alterations, gene regulation, complex inheritance), including new genomics / functional genomics technologies, multi-omics, mathematics, biostatistics, bioinformatics and artificial intelligence approaches;
  4. Functional strategies to globally stratify variants of unknown significance (VUS) for clinical use; setting up of (in vitro) systems to distinguish between VUS and pathogenic variants (e.g. confirming disruption of splicing for deep intronic variants, loss of protein function, and gain of toxic protein function);
  5. Development of pathway models to enable diagnosis, especially for newly discovered diseases that may share underlying molecular mechanisms with already known diseases.

The following approaches and topics are excluded from the scope of the call JTC2022:

  • Interventional clinical trials to prove efficacy of drugs, treatments, surgical procedures, medical technology procedures. This also includes studies comparing efficacy, e.g. two surgical techniques or therapies. Clinical phase IV pharmacovigilance studies cannot be funded either.
  • Studies on the exclusive testing of the safety of medical devices.
  • Development of new therapies as covered in EJP RD JTC 2020.
  • Projects focusing only on rare neurodegenerative diseases which are within the main focus of the Joint Programming Initiative on Neurodegenerative Disease Research (JPND). These are: Alzheimer’s disease and other dementias; Parkinson’s disease (PD) and PD-related disorders; Prion diseases; Motor Neuron Diseases; Huntington’s disease; Spinal Muscular Atrophy and dominant forms of Spinocerebellar Ataxia. Interested researchers should refer to the relevant JPND calls. However, childhood dementias/neurodegenerative diseases are not excluded.
  • Rare infectious diseases, rare cancers and rare adverse drug events in treatments of common diseases. Rare diseases with a predisposition to cancer are not excluded.

Consortium makeup:

  • The project consortium should include 4 partners from at least 4 different countries participating in the call.
  • A maximum of 2 partners from the same country can take part in the project consortium.
  • The duration of the project should be a maximum of 3 years.
  • Only international projects will be supported.

Important Information

Project proposals to be submitted from Turkey will be supported within the scope of TÜBİTAK 1071- Support Program for Increasing the Capacity to Benefit from International Research Funds and Participation in International R&D Collaborations.

EJP RD Partner Search Tool: If you are looking for a partner to apply for the call, you can find partners using the EJP RD Partner Search Tool https://live.eventtia.com/en/jtc2022matchmaking

For detailed information about the call, please click here.

For accessing the call application documents and guide, please click here.

It is obligatory to make a national application to the call. Click here to access the national application process document.

Call Contacts

For information on International Application Requirements and EJP RD:

Dr. Jale ŞAHİN

TÜBİTAK, Directorate for International Cooperation (UİDB)

jale.sahin@tubitak.gov.tr

For information on National Application Requirements:

Ebru İMAMOĞLU

TÜBİTAK, International Cooperation Projects Research Support Group (UPAG)

ebru.imamoglu@tubitak.gov.tr

 

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